DURING World War II the incidence of ocular injuries was unusually high. Recent reports have pointed out that a wide variety of agents affect adversely the healing of the epithelial defects of the cornea. No agent has yet been discovered which increases the rate of healing.
I1 have demonstrated that sulfonamide compounds in the form of powder, ointment or emulsion retard the regeneration of the epithelium of the cornea and promote the formation of scar tissue and vascularization. Smelser and Ozanics2 showed that sulfathiazole and sulfacetimide inhibit cell migration after corneal burns. Sulfadiazine and penicillin produce only slight inhibitory effects. Berens, de Gara and Loutfallah3 demonstrated that corneal wounds healed more slowly when treated with a sulfonamide ointment or with the ointment base alone than when the wounds were untreated. Sulfonamide ointment delayed the healing of deeper wounds more than that of superficial ones. Leopold and Steele
JOHN G. BELLOWS. INFLUENCE OF LOCAL ANTISEPTICS ON REGENERATION OF CORNEAL EPITHELIUM OF RABBITS. Arch Ophthalmol. 1946;36(1):70–81. doi:10.1001/archopht.1946.00890210073005