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September 1946


Author Affiliations

From the Department of Ophthalmology of Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

Arch Ophthalmol. 1946;36(3):284-292. doi:10.1001/archopht.1946.00890210291002

FAVORABLE reports have been made on the treatment of certain surface infections of the border of the lid, the conjunctiva and the cornea with penicillin ointments. Florey and Florey1 used a penicillin salve with a pure petrolatum base. Keyes2 applied penicillin in a wool fat and cold cream base, and Cashell3 in a lanette wax base.4 In an earlier experimental investigation in this laboratory5 the penetrability of three ointments, representing two types of emulsion systems (anhydrous wool fat containing 10 per cent liquid petrolatum and an oil-in-water emulsion) was studied; similar investigations were conducted by Bellows6 with four bases and by Leopold and LaMotte7 with a Carbowax (a polyethylene glycol) base. The cited experimental studies were, however, concerned mostly with the penetration from a few ointments, generally containing the sodium salt of penicillin. It was desirable, therefore, to extend the investigations and to