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May 1947

EXPERIMENTAL STUDIES ON THE BLOOD-AQUEOUS BARRIER: II. Electrophotometric Measurements of Fluorescein Content of Aqueous After Intravenous Injection of Fluorescein, the Eye Being Under the Influence of Physostigmine, Pilocarpine, Neostigmine or Atropine1

Author Affiliations

From the Department of Surgery, Ophthalmological Division, Duke University School of Medicine.

Arch Ophthalmol. 1947;37(5):583-586. doi:10.1001/archopht.1947.00890220600003

IT HAS been demonstrated by numerous authors, especially by the splendid work of Duke-Elder2 and Friedenwald3 and their co-workers, that the penetration of the various constituents of aqueous through the blood-aqueous barrier follows a rather complicated scheme. Electric charge, size of the molecule and possibly other factors influence the ratio of transmission of each constituent. But, on the other hand, it has also been shown that any change of the permeability of the blood-aqueous barrier will affect all constituents to a certain extent, though not equally, whether they are electrolytes, nonelectrolytes or proteins. To mention only two examples, Krause, Yudkin, Stevens, Burmell and Hughson4 found an increase in the amount of arsenic present in the aqueous after intravenous injection of arsphenamines if the eye had been previously pilocarpinized, and Adler5 demonstrated a decrease in the permeability of the blood-aqueous barrier to protein in spite of the

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