IONTOPHORESIS (ion transfer, ionization) has been employed in general medicine for over one hundred years. Although it has been used in the treatment of diseases of the eye for more than fifty years, it is still a comparatively unknown form of ocular therapy. From three to fifteen times greater concentrations of drugs can be obtained in the tissues of the conjunctiva, cornea and anterior segment of the eye by iontophoresis than by the topical application of the same drugs. For this reason mydriasis can usually be obtained by the iontophoretic introduction of atropine sulfate in the case of pupils that are refractory to the topical application or the subconjunctival injection of mydriatics. Anterior synechias may also be broken by this method when other methods fail. The theories and experimental and clinical data of iontophoresis as they apply to general medicine are thoroughly discussed by Abramowitsch and Neoussikine1 in their
SELINGER E. IONTOPHORESIS WITH CONTACT LENS TYPE AND EYECUP ELECTRODES: Some Points of the Theory and Technic of Ion Transfer. Arch Ophthalmol. 1947;38(5):645–653. doi:10.1001/archopht.1947.00900010662004
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