THE FIRST primary cranial epidermoid was reported by Johannes Müller1 in 1838. He called attention to the resemblance between cells of epidermal origin and the cells observed in these tumors. Remak, in 1854, advanced the theory of ectodermal rests to explain the origin of epithelial tumors having no attachment to the surface epithelium. Bostroem,2 in 1897, first used the term epidermoid and pointed out the many opportunities for bits of ectoderm to be pinched off during closure of the neural tube and during subsequent stages in the development of the central nervous system, as when the transverse folds are forming. He expressed the belief that only cell rests in contact with the pia or lodged in the diploe are assured of nourishment adequate to develop into tumors. He stated that when cells destined only for the epidermis are pinched off they give rise to tumors exhibiting only epidermoid
GIVNER I, WIGDERSON H. CRANIAL EPIDERMOID WITH EROSION OF THE ROOF OF THE ORBIT: Report of a Case. Arch Ophthalmol. 1948;39(3):300–304. doi:10.1001/archopht.1948.00900020307004
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