[Skip to Navigation]
August 1948

LATTICE TYPE OF HEREDITARY CORNEAL DEGENERATION: Report of Five Cases, Including One of a Child of Two Years

Author Affiliations

From the Institute of Ophthalmology of the Presbyterian Hospital of the City of New York.

Arch Ophthalmol. 1948;40(2):189-217. doi:10.1001/archopht.1948.00900030194010

THE LATTICE type of familial corneal dystrophy was first described in 1890 by Hugo Biber,1 a pupil of Haab, as gitterige Keratitis. He called it a chronic disease of the cornea, producing a bilateral opacity which at first looked like the residue of interstitial keratitis. The margin of the cornea was spared. Close examination revealed that the opacity was due to a lattice-like system of lines and to fine, rounded dots, which together resembled a spider's web. In regard to the lines, Biber said:

They run in various directions and sometimes cross each other. They remind one of a birch twig, branching here and there. Ledgelike projections on the surface of the cornea appear to correspond to these lines.1

Symptoms of inflammation were insignificant, and at most included slight congestion and photophobia. The disease ran a long and painless course, eventually resulting in serious impairment of vision. Biber

Add or change institution