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October 1948

STUDIES IN EXPERIMENTAL OCULAR TUBERCULOSIS: XII. Effect of Streptomycin and "Promizole" on Experimental Ocular Tuberculosis in the Immune-Allergic Rabbit

Author Affiliations

From the Wilmer Ophthalmological Institute of the Johns Hopkins Hospital and University.

Arch Ophthalmol. 1948;40(4):413-432. doi:10.1001/archopht.1948.00900030425003

IN PREVIOUS communications1 there were reported the results of experiments which dealt with the possible therapeutic effect of one antibiotic and two chemotherapeutic agents on experimental ocular tuberculosis. It was found la that penicillin G, given in enormous doses, has no deterrent action on the progress of ocular tuberculosis in the normal (nonimmune) rabbit. It was further reported 1b,c that two sulfones, "promin" (N,N′-didextrose sulfonate, the sodium salt of p,p′-diaminodiphenyl sulfone) and "promizole" (4,2′-diaminophenyl-5′-thiazolylsulfone) had a deterrent effect on the ocular disease. This was apparent in both the immune-allergic and the normal rabbit, although in the normal animal the effect was not marked. In the normal rabbit, a slight decrease in the ocular inflammation was noted at the end of the second week of treatment, and this was clinically most noticeable after eight weeks of treatment. However, transmission experiments of inoculum from the eyes of the treated animals at

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