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November 1949

EXPERIMENTAL STUDIES ON THE VITREOUS: I. Experiments on Diffusion in the Vitreous and on Permeability of Its Surface Condensation Layer

Author Affiliations

From the Department of Ophthalmology, Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

Arch Ophthalmol. 1949;42(5):583-595. doi:10.1001/archopht.1949.00900050593008

CLINICAL experience and scattered experimental data indicate that diffusion in the vitreous is slow.1 These observations were confirmed in systematic studies of Fischer2 on diffusion of hemoglobin in arbitrarily divided samples of vitreous and in examinations on spreading of penicillin after intravitreal injection in the living eye.3 New information on this subject was gained by Kinsey, Grant and Cogan4 in determining the total movement of vitreous water, with deuterium oxide (heavy water; D2O) as a tracer substance. The authors concluded from their experiments that the movement of water in the rabbit vitreous was of a magnitude of about 85 cu. mm. per minute. Studies on the eye with radioactive sodium (Na24) autographs5 provided instructive photographic imprints on diffusion of this normal body constituent in rabbit eyes under physiologic conditions. It was distributed homogeneously throughout the vitreous two to four hours after intraperitoneal

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