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May 1950

STUDIES IN EXPERIMENTAL OCULAR TUBERCULOSIS: XIV. Failure of Aureomycin to Affect the Course of Ocular Tuberculosis

Author Affiliations

From the Wilmer Ophthalmological Institute of the Johns Hopkins Hospital and University.

Arch Ophthalmol. 1950;43(5):845-848. doi:10.1001/archopht.1950.00910010860007

AUREOMYCIN has been shown to be successful in the treatment of a wide variety of infectious diseases.1 It has also been shown that resistance to aureomycin by many organisms is developed much more slowly and to a less degree than is resistance to streptomycin.2 Braley and Sanders3 reported 2 cases of tuberculous uveitis in which decided improvement followed treatment with aureomycin. Schoenbach4 treated 6 patients with various forms of tuberculosis. Two of these 6 showed improvement, 1 with a renal infection, the other with scrofulous draining sinuses of the neck.

Steenken and Wolinsky5 found the in vitro sensitivity of the H37 RV strain of Mycobacterium tuberculosis to vary from 5 to 40 micrograms per cubic centimeter, depending on the medium used for the assay. These authors treated the disease in guinea pigs with aureomycin and concluded that the course of the clinical disease was not

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