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December 1950


AMA Arch Ophthalmol. 1950;44(6):842-853. doi:10.1001/archopht.1950.00910020855007

BRILL, Baehr and Rosenthal1 (1925) described a syndrome that is characterized by follicular hyperplasia of the lymph nodes, often accompanied with splenomegaly, and remarkably remediable with roentgen irradiation. It has been accepted generally as a specific disease. Numerous case reports and several monographs have dealt with it. Symmers (1938)2 published the first large paper, and the disease is often called the Brill-Symmers syndrome. The usual terms in the United States literature are "follicular lymphoblastoma" and "giant follicular lymphadenopathy." The disorder is fairly well defined, and after histological examination of a lymph node the diagnosis is usually easy. The number and size of the follicles are increased; the cellular tissue is composed of comparatively large cells with numerous mitoses and tends to invade the fibrous capsule; often the entire lymphadenoid system is involved, but sometimes certain groups of glands only are affected; usually the blood picture is completely normal

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