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Article
May 1951

STUDIES IN EXPERIMENTAL OCULAR TUBERCULOSIS: XV. Effect of Paraaminosalicylic Acid and of Streptomycin plus Paraaminosalicylic Acid in Normal Rabbits

AMA Arch Ophthalmol. 1951;45(5):546-554. doi:10.1001/archopht.1951.01700010558007
Abstract

SINCE the first reports by Lehmann1 in 1946 on the use of paraaminosalicylic acid in tuberculosis, there have been an increasing number of reports on its value in experimental and human tuberculosis, both alone and in combination with streptomycin. The subject has recently been reviewed.2 There have been a number of recent reports on the use of paraaminosalicylic acid in experimental ocular tuberculosis, as well as in cases diagnosed as ocular tuberculosis in humans.3

The following studies were undertaken to determine the effect of paraaminosalicylic acid, both alone and in combination with streptomycin, on experimental ocular tuberculosis in the normal rabbit. At the same time, these effects were compared with the effect of streptomycin and thiazolsulfone (promizole®; 4, 2′-diaminophenyl-5′-thiazolylsulfone) on experimental ocular tuberculosis in the normal rabbit.

EXPERIMENTAL STUDIES  Sixty-four healthy, normal adult rabbits, of mixed sex, averaging approximately 2,500 Gm. in weight, and of the same

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