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August 1951


Author Affiliations

From the Howe Laboratory of Ophthalmology, Harvard Medical School, and the Massachusetts Eye and Ear Infirmary.

AMA Arch Ophthalmol. 1951;46(2):113-131. doi:10.1001/archopht.1951.01700020119001

IT IS THE purpose of this paper to report certain observations on facility of outflow and rate of formation of aqueous humor in human beings. Special consideration will be given to those changes which are concerned in the pathogenesis of glaucoma. The basis for this report is provided by measurements made on patients' eyes by means of a tonographic method, already published.1 Approximately 1,000 of these measurements have been made on 600 clinically examined eyes. a majority of which were glaucomatous.

This study makes available a quantitative method of evaluating glaucoma. Specifically, it enables one to evaluate the respective roles of resistance to outflow and rate of formation of aqueous humor. This possibility has apparently not previously been explored in the manner of the present study. Previous investigations of aqueous outflow have yielded information only in terms which have left it undetermined whether the changes which were detected in

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