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December 1951


AMA Arch Ophthalmol. 1951;46(6):668-676. doi:10.1001/archopht.1951.01700020682010

ALTHOUGH occlusion of the central retinal vein is a commonly seen clinical - entity, separated from the group of so-called hemorrhagic retinopathies over 70 years ago, there has been no universal agreement concerning its etiology or pathogenesis. This is well illustrated by the numerous forms of treatment which have been employed and the conflicting reports of their success.

The first published report of the pathologic findings in occlusion of the central retinal vein was that of von Michel,1 who described two cases in 1878 and reported a third 21 years later. He suggested that the occlusion in his first case might be due to proliferation of the intima, but ascribed the occlusion to thrombi in the other two cases. In the next 25 years 20 more cases were reported,2 in 10 of which thrombi were stated to be the cause of the occlusion. One showed proliferation of the endothelium,

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