THIS STUDY was undertaken to evaluate the new antibiotic terramycin. This was done by simultaneous comparison with other agents, namely, neomycin, chloramphenicol (chloromycetin®), aureomycin, and streptomycin, against standard pure-culture corneal infections of the rabbit eye. Terramycin has a wide antibacterial spectrum (Table 1).1
In studying the course and treatment of corneal ulcers, it has been found that the eyes of experimental animals lend themselves well to the production of standard infections which can be accurately observed.2
The organisms selected for the present study were chosen for their resistance to the commonly employed therapeutic agents and their ability to produce corneal ulcerations of desired severity (Table 2).
Preparation of the Organsim.
—After centrifuging a pure 18-hour trypticase-soy broth culture of a strain of Pseudomonas aeruginosa, the supernatant fluid was decanted and sterile isotonic solution of sodium chloride was added to the packed organisms. The organisms were then dispersed
CANNON EJ, LEOPOLD IH. EFFECTIVENESS OF TERRAMYCIN AND OTHER ANTIBIOTICS AGAINST EXPERIMENTAL BACTERIAL KERATITIS. AMA Arch Ophthalmol. 1952;47(4):426–436. doi:10.1001/archopht.1952.01700030436004
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