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April 1952

STUDIES IN EXPERIMENTAL OCULAR TUBERCULOSIS: XVI. Effect of Corticotropin, Cortisone, and Compound F on Development of Experimental Ocular Tuberculosis in Immune-Allergic and Normal Rabbit

AMA Arch Ophthalmol. 1952;47(4):477-512. doi:10.1001/archopht.1952.01700030487010

IN A PREVIOUS communication1 it was pointed out that the parenteral injection of corticotropin (ACTH) and cortisone in immune-allergic rabbits with secondary ocular tuberculosis, produced by injection of tubercle bacilli into the anterior chamber, somewhat altered the course of the disease in such eyes. It was found that the administration of corticotropin and cortisone to these animals, prior to the parenteral injection of tuberculin, blocked the focal ocular reaction which was constantly observed in the untreated controls. It was further found that the continued use of cortisone for a three-week period in such animals appeared to control the inflammatory phase of the ocular tuberculosis, leaving the peculiar picture of uninflamed eyes with active tubercles in the iris or cornea.

In this experiment it was not clear whether this suppression of the inflammation had any effect on the actual progress of the tuberculous process in the eyes. This point was

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