THIS paper presents observations made during the treatment of 17 premature infants with vitamin E and of 21 premature infants with corticotropin (ACTH) or cortisone. We have concluded from these experiences that none of these substances offers an effective means of therapy for the condition. Although it is difficult, because of the unpredictable course of the disease and the small number of patients available, to state that these substances may not favorably influence the condition in certain instances, they are certainly not curative in all. The disease progressed to blindness in some patients in spite of therapy with vitamin E, corticotropin, or cortisone, while in others it became arrested or even regressed to normal. We do believe, however, that further therapeutic trial of these substances is justified until sufficient evidence has accumulated to indicate their complete ineffectiveness or until a truly satisfactory means of treatment is available. No danger accompanies
LA MOTTE WO, TYNER GS, SCHEIE HG. TREATMENT OF RETROLENTAL FIBROPLASIA WITH VITAMIN E, CORTICOTROPIN (ACTH), AND CORTISONE. AMA Arch Ophthalmol. 1952;47(5):556–569. doi:10.1001/archopht.1952.01700030570002
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