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June 1952

POSSIBLE MALIGNANT MELANOMA OF CHOROID: Pathologic Study of a Minute Tumor Discovered in an Enucleated Phthisical Eye

Author Affiliations

From the Departments of Pathology of the Brooklyn Hospital and the Brooklyn Eye and Ear Hospital.

AMA Arch Ophthalmol. 1952;47(6):734-744. doi:10.1001/archopht.1952.01700030753005

IT IS AXIOMATIC that the retention of a sightless eye in adult life, especially one in which the interior structures cannot be visualized, is a hazard because of the possibility of the development of malignant melanoma under circumstances that preclude its early detection. In the case to be discussed below, a small pigmented choroidal tumor was discovered by chance in an enucleated phthisical eye. The growth was in close relation to a long ciliary nerve. Pigment was so abundant that few details of structure were visible, so that reduction of the pigmentation by bleaching was necessary. The cellular details so revealed suggested the advisability of discussion of the problem of establishing the benign or malignant nature of this particular lesion and of neoplasms in general.

The presence of phthisis bulbi, which alone had been clinically apparent and which tended to mask the tumor on histologic examination, contributed collateral features of

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