THIS REVIEW was undertaken to determine the nature of the relationship of Leber's hereditary optic atrophy to the other heredodegenerative diseases of the nervous system. It is well known that hereditary optic atrophy has often occurred in conjunction with Marie's hereditary cerebellar ataxia of varying degrees of severity. It is little known that Leber's atrophy may occur with the familial ataxia of Friedreich and with the hereditary spastic paraplegia of Strümpell, the Charcot-Marie-Tooth peroneal muscular atrophy, and the hypertrophic neuritis of Dejerine and Sotta. Other syndromes have recently been added to this impressive group.
A brief diagrammatic sketch of the neurological lesions and nomenclature involved will serve as a review of these confusing syndromes. They are usually discussed as separate nervous diseases, named after some neurologist and unrelated except by the fact that they all are hereditary. The present method of presentation was first used in a paper by Aring
BEREDAY M, COBB S. RELATION OF HEREDITARY OPTIC ATROPHY (LEBER) TO OTHER FAMILIAL DEGENERATIVE DISEASES OF CENTRAL NERVOUS SYSTEM. AMA Arch Ophthalmol. 1952;48(6):669–680. doi:10.1001/archopht.1952.00920010681001
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