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December 1952

SURGERY OF OCULAR TRAUMA: Therapy of Secondary Intraocular Infection

Author Affiliations

From Wills Hospital.

AMA Arch Ophthalmol. 1952;48(6):738-746. doi:10.1001/archopht.1952.00920010750010

IN THIS antibiotic age one would expect the incidence of post-traumatic intraocular infection to be almost nil. Unfortunately, too many traumatized eyes have been lost because of intraocular infection. It is disheartening to see secondary infection develop within 24 hours after an otherwise uneventful, rapid extraction of an intraocular foreign body. This has occurred in spite of prophylactic and post-operative administration of antibiotics.

Within the past three months six cases of intraocular infection associated with penetrating foreign bodies have been encountered (Table 1).

Several noteworthy facts can be gleaned from these cases. In all of them penicillin or penicillin and streptomycin were given systemically before operation. The dose varied from 300,000 to 600,000 units of penicillin, injected intramuscularly. Streptomycin was administered in a dose of 0.5 to 1 gm. daily. In spite of such therapy, infection developed in all cases. This means either that the organism responsible was not sensitive

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