INFECTIONS of the eye due to virulent strains of Pseudomonas aeruginosa have a serious prognosis. Treatment has been relatively ineffective, as evidenced by the large number of patients undergoing enucleation or having severe loss of vision after such infections. The combined use of polymyxin B and "varidase" (streptokinase-streptodornase) were of distinct therapeutic help in the case to be reported.
It has been demonstrated that polymyxins are superior to all other antibiotics in the treatment of infections produced by Ps. aeruginosa. Currently, polymyxin B is available for therapeutic purposes. If the total daily dose of this agent is kept below 2.5 mg. per kilogram of body weight, the chances of the patient's having toxic reactions, such as renal damage or neurological lesions, are minimal. It would appear, also, that the dangers of tissue sensitization from the local use of the polymyxins are slight.
"Varidase" is a tool for the removal of
VINCENT O. EARECKSON, JOSEPH M. MILLER, PERRIN H. LONG. INFECTION OF EYE DUE TO PSEUDOMONAS AERUGINOSA TREATED WITH POLYMYXIN B AND ``VARIDASE''. AMA Arch Ophthalmol. 1953;49(2):158–160. doi:10.1001/archopht.1953.00920020163003
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