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September 1953

DIBENAMINE: An Experimental and Clinical Study

Author Affiliations

From the Department of Ophthalmology, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Graduate School of the University of Pennsylvania, and the Children's Hospital.

AMA Arch Ophthalmol. 1953;50(3):289-298. doi:10.1001/archopht.1953.00920030296005

DIBENAMINE is a nitrogen mustard derivative, first introduced by Nickerson1 in 1946, which possesses specific and highly potent sympatholytic and adrenolytic properties. Nickerson and Goodman2 subsequently elaborated upon the pharmacological characteristics of the substance. Ophthalmologic interest in the drug was stimulated in 1948 by Christensen, Swan, and Gould,3 who reported favorable effects in the treatment of acute glaucoma with Dibenamine.

This paper presents certain experimental data concerned with the mechanism of action of Dibenamine in lowering intraocular pressure and our experiences with the drug in the treatment of a small number of patients with acute glaucoma.

PURPOSE OF EXPERIMENTS  The way in which Dibenamine lowers the intraocular pressure in glaucoma has never been determined. We felt that several possibilities should be investigated and devoted our experimental studies to the following factors: (1) alterations in the permeability of the blood-aqueous barrier; (2) changes in rate of flow of

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