CAMPBELL,1 of Australia, in July, 1951, published observations on a series of cases of retrolental fibroplasia which suggested that the disease might be due to excessive administration of oxygen.* Since this time, Campbell's experiences have been shared by several investigators in different parts of the world: by Ryan,3 in Australia; by Crosse and Evans,4 in England; by Patz, Hoeck, and De La Cruz,5 in the United States, and by Goldman and Tobler,6 in Switzerland, to mention a few.
However, in December, 1951, and again in March, 1952, the opposing view was propounded by Szewczyk,† of St. Louis, namely that the disease was due to anoxia, and that oxygen not only could prevent the disease but would also be effective in its therapy. Szewczyk's views have been given some support by Ingalls9 on the basis of laboratory studies; as a result of these directly opposing
LOCKE JC. RETROLENTAL FIBROPLASIA: Definitive Role of Oxygen Administration in Its Etiology. AMA Arch Ophthalmol. 1954;51(1):73–79. doi:10.1001/archopht.1954.00920040075010
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