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January 1954

RETROLENTAL FIBROPLASIA: Definitive Role of Oxygen Administration in Its Etiology

Author Affiliations

From the Institute of Ophthalmology of the Presbyterian Hospital, New York, and from the Department of Ophthalmology of the Royal Victoria Hospital.

AMA Arch Ophthalmol. 1954;51(1):73-79. doi:10.1001/archopht.1954.00920040075010

CAMPBELL,1 of Australia, in July, 1951, published observations on a series of cases of retrolental fibroplasia which suggested that the disease might be due to excessive administration of oxygen.* Since this time, Campbell's experiences have been shared by several investigators in different parts of the world: by Ryan,3 in Australia; by Crosse and Evans,4 in England; by Patz, Hoeck, and De La Cruz,5 in the United States, and by Goldman and Tobler,6 in Switzerland, to mention a few.

However, in December, 1951, and again in March, 1952, the opposing view was propounded by Szewczyk,† of St. Louis, namely that the disease was due to anoxia, and that oxygen not only could prevent the disease but would also be effective in its therapy. Szewczyk's views have been given some support by Ingalls9 on the basis of laboratory studies; as a result of these directly opposing

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