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February 1954

STUDIES IN EXPERIMENTAL OCULAR TUBERCULOSIS: XVII. Effect of Isoniazid in the Normal, Nonimmune Rabbit

AMA Arch Ophthalmol. 1954;51(2):242-255. doi:10.1001/archopht.1954.00920040244011

THE CHEMOTHERAPEUTIC agents available for the use against the Mycobacterium tuberculosis have been divided into two general groups1: (a) the antibiotics and (b) the synthetics.

The one antibiotic with a demonstrated specific action in tuberculosis is streptomycin. The action of this agent, by itself and in conjunction with various synthetics, has been extensively studied and reported upon,* both in experimental and in clinical ocular tuberculosis. The therapeutic value of streptomycin plus an adjuvant is now clearly established.

The synthetics may be subdivided into (1) the sulfones, (2) the aminohydroxybenzoic acids, (3) the thiosemicarbazones, and (4) the pyridine-carboxylic acid derivatives. A brief summary of these various groups follows.

  1. The Sulfones. The first sulfone discovered with a specific bacteriostatic or bacteriocidal action against the Myco. tuberculosis was sulfoxone sodium (Diasone; disodium formaldehyde sulfoxylate diaminodiphenylsulfone6). The clinical use of this agent was, however, impossible on account of its high toxicity. Various other

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