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May 1954

OUTFLOW OF AQUEOUS HUMOR: Biomicroscopic Estimation Compared with Tonographic Measurement

Author Affiliations

From the Department of Ophthalmology, University of Cincinnati College of Medicine.; Formerly Research Assistant, Department of Ophthalmology, University of Cincinnati College of Medicine (Dr. Stepanik). Former resident, Department of Ophthalmology, University of Cincinnati (Lieutenant Kemper).

AMA Arch Ophthalmol. 1954;51(5):671-680. doi:10.1001/archopht.1954.00920040681011

THE PURPOSE of this work was to determine quantitatively the biomicroscopically visible outflow of aqueous humor in normal eyes and to compare this value with the total aqueous outflow. In other words, we attempted to determine to what extent the clear or almost clear aqueous veins participate in the transport of aqueous.

The first attempt to estimate the flow of aqueous humor was carried out by Hovius,* who opened the anterior chambers of dogs' eyes and measured the aqueous flowing out of the wound. The surprisingly high values which this experiment gave (130 cu. mm. per minute) were correctly attributed to the gross disturbance of the physiologic relationship resulting from opening the anterior chamber.† Direct measurement by cannulating the anterior chamber while maintaining normal intraocular pressure gave essentially lower results (Leber and Benson, Priestly Smith, Niesnamoff ‡). Using the same experimental arrangement, while blocking the chamber angle by means of

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