A SERIES of trustworthy investigations indicates that distribution of trachoma virus is confined to the epithelial layer of the conjunctiva.* Nevertheless, the significant clinical change in trachoma is subepithelial inflammation, e. g., follicle formation and cellular infiltration. In addition, in the acute stage of infection there is often the association of a preauricular adenopathy. Might these changes not be incurred by a toxin or toxin-like substance produced by the trachoma virus? On the other hand, a toxin or a similar factor has been demonstrated in related viruses, namely, the viruses of psittacosis and lymphogranuloma venereum. The problem as to whether trachoma virus produces a toxin or like substance may, therefore, be worthy of investigation.
DESIGN OF THE EXPERIMENT
Conjunctival matter from trachoma cases with a great number of inclusion bodies no doubt contains trachoma virus in high concentration. If a soluble toxin or toxin-like substance is being produced by the
MITSUI Y, TANAKA C, YAMASHITA K, HANABUSA J. TOXIN-LIKE SUBSTANCE OF TRACHOMA VIRUS. AMA Arch Ophthalmol. 1954;52(1):72–76. doi:10.1001/archopht.1954.00920050074008
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