THE MECHANISMS responsible for the production and maintenance of the ocular complications of hyperthyroidism have not been entirely elucidated. Accordingly, the rate of removal of radioactive sodium from the orbits of healthy human subjects and of patients with the mild and severe extremes of ophthalmopathy has been observed with a view toward determining whether venous obstruction or active inflammation accounts for the phenomena. The extremes of the eye changes have been variously termed "thyrotoxic" and "thyrotropic," or "simple" and "malignant" exophthalmos, among other names, but in this paper they will be called "mild" and "severe."
It has been recognized that orbital tension is increased in the severe form of thyroid ophthalmopathy. Quantitative measurements reveal an increase proportionate to the degree of exophthalmos.1 Rundle and Pochin2 have shown also that there is a significant increase in orbital bulk which tends to correlate quantitatively with the degree of exophthalmos. This
DAY RM, WERNER SC. REMOVAL RATE OF RADIOSODIUM (Na24) FROM HUMAN ORBIT IN GRAVES'S DISEASE AND IN HEALTH. AMA Arch Ophthalmol. 1954;52(1):85–90. doi:10.1001/archopht.1954.00920050087010
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