THE ELECTRICAL potential developed in the human retina upon stimulation by light is detected and recorded, by the technique described by Karpe,1 as the electroretinogram (ERG). The amplitude of this potential has been shown, by Henkes2 (1951), to increase upon the systemic administration of vasodilator drugs.
With the knowledge that vasodilators cause an increase in the amplitude of the b-wave of the ERG, it was thought that the electroretinographic technique might allow for graphic comparison of the relative efficacy of several vasodilators upon retinal blood flow. Accordingly, four common vasodilating drugs were selected and studied. In addition, the effect of a unilateral stellate ganglion block using 1% lidocaine (Xylocaine) hydrochloride was determined. The stellate ganglion block was performed on the same side as that used for measuring the ERG's. Serial ERG's were taken before and after the administration of the drugs and block.
The four drugs used and
JACOBSON JH, LINCOLN MW. EFFECT OF VASODILATOR DRUGS AND STELLATE GANGLION BLOCK UPON THE ELECTRORETINOGRAM. AMA Arch Ophthalmol. 1954;52(6):917–922. doi:10.1001/archopht.1954.00920050923010
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