DIFFICULTIES encountered in the differential diagnosis, in the eyes of two patients, of almost identical unilateral elevated macular lesions, one benign, the other malignant, provided the stimulus for this paper. Both eyes were enucleated, with a clinical diagnosis of malignant melanoma of the macula. Because one proved to be a disciform degeneration with an unusual degree of elevation, a study of non-neoplastic lesions of the macula was undertaken with the hope of gaining information which might help to avoid such errors in the future. Permission was obtained from the Armed Forces Institute of Pathology to study sections of 23 eyes coded as disciform degeneration of the macula in the Registry of Ophthalmic Pathology.
The differential diagnosis of macular lesions producing elevation is primarily concerned with malignant melanoma and senile disciform degeneration of the macula. Other lesions which occur considerably less frequently include (1) choroidal or subretinal hemorrhage, (2) metastatic carcinoma,
FRAYER WC. ELEVATED LESIONS OF THE MACULAR AREA: A Histopathologic Study Emphasizing Lesions Similar to Disciform Degeneration of the Macula. AMA Arch Ophthalmol. 1955;53(1):82–92. doi:10.1001/archopht.1955.00930010084008
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