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February 1955


Author Affiliations

From the Howe Laboratory of Ophthalmology, Harvard Medical School, and Massachusetts Eye and Ear Infirmary.

AMA Arch Ophthalmol. 1955;53(2):191-200. doi:10.1001/archopht.1955.00930010193003

IT WAS THE purpose in this investigation to examine the relationship of intraocular pressure, volume of the eye, and rate of outflow of the aqueous humor by direct methods and to evaluate these factors as they bear on the indirect methods of clinical tonography.

The present work constitutes the second part of a general study of the outflow of the aqueous humor, the first part of which was the development and application of tonography.* A third part, to be reported separately, is concerned with the anatomical and physiological factors responsible for the resistance to outflow from normal eyes and glaucomatous eyes.4

Clinical tonography has indicated that the outflow of aqueous normally encounters a resistance which becomes greater than normal in all types of glaucoma, and that this increased resistance is the principal cause of increased intraocular pressure in glaucoma.2 Also, in conjunction with gonioscopy, tonography has helped establish

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