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February 1955

MELANOBLASTS OF THE NORMAL HUMAN CHOROID: Study with Silver Carbonate and Silver Nitrate

Author Affiliations

Ann Arbor, Mich.
From the Laboratory of Neuropathology and Neuro-ophthalmology, Neuropsychiatric Institute, University of Michigan Hospital.

AMA Arch Ophthalmol. 1955;53(2):211-214. doi:10.1001/archopht.1955.00930010213006

THE MELANOBLASTS constitute an important element of the choroid of the human eye, but their morphology and physiology have attracted little attention; they are generally considered as elements without particular function and of limited biologic significance, destined only to fill out the space. That such a view is not justified can be demonstrated with modern silver methods, which disclose an intricate relationship between the melanoblasts and other elements of the choroid; this relation suggests that these pigmented cells have important functions.

MATERIAL AND METHODS  The tissue examined was that of normal human eyes. Figures 1 to 7 were prepared with the silver carbonate method of del Rio Hortega without reduction (Scharenberg and Zeman1). This technique permits a complete impregnation also of those segments of processes of the melanoblasts that, according to Lauber,2 contain only colorless premelanotic pigment. This substance stains black with colloid silver, so that all parts

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