Conflicting clinical reports * have recently been published concerning the role of androgens and estrogens in diabetic retinopathy. Unfortunately, neither bioassays nor chemical analyses for tissue levels of these hormones are sufficiently accurate to support the endocrine hypotheses involved. Because of the divergent clinical conclusions and the current impassé in obtaining quantitative hormonal assays, a controlled laboratory study has been undertaken in an experimental diabetic animal. Albino rats rendered diabetic by alloxan were used, it being recognized that retinal vascular changes in the rat, as in most experimental diabetic animals, have been produced only with difficulty,† and only in the presence of some additional disturbance or tissue insult. Supplemental estrone was given to one group of diabetic rats in accordance with the hypothesis that this might precipitate additional tissue insult leading to retinopathy. Similarly, testosterone was given to another group on the basis that it might protect against the development of
KEENEY AH, BARLOW FD. Supplemental Testosterone and Estrone in Alloxan Diabetes of the Rat. AMA Arch Ophthalmol. 1955;53(3):407–410. doi:10.1001/archopht.1955.00930010409014
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