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May 1955

Intravenous Treatment of Optic Neuritis: Comparison of Corticotropin and Typhoid Bacilli

Author Affiliations

From the Department of Ophthalmology, The Cleveland Clinic Foundation, and The Frank E. Bunts Educational Institute.

AMA Arch Ophthalmol. 1955;53(5):700-701. doi:10.1001/archopht.1955.00930010708013

There are many reports in the current literature on the intravenous use of corticotropin and of typhoid; however, there are no articles comparing their clinical use in ophthalmology. This study was undertaken in order to ascertain the clinical value of intravenous corticotropin (ACTH; adrenocorticotropic hormone) in comparison with that of intravenous killed typhoid bacilli in the treatment of optic neuritis: We have compared the results of treatment in two groups of patients, one in which the treatment was with corticotropin and the other in which it was with killed typhoid bacilli.

It has been shown by Olson and associates1 that nonspecific foreign protein, i. e., killed typhoid organisms, among other drugs, produces changes in the adrenal cortex which are characteristic of the general response to stress, and that the benefit derived from this form of therapy could be attributed to the release of endogenous adrenocorticotropic hormone.* The same type

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