The lowering of intraocular pressure by the systemic administration of acetazoleamide (Diamox)1 and other carbonic anhydrase inhibitors * has stimulated rather widespread interest in the use of these agents in the therapy of the glaucomas.†
Considerable evidence has been accumulated to suggest that the mode of action of these pressure-lowering agents is a partial suppression of secretion of the aqueous humor.4 This hypothesis was based primarily upon tonographic and fluorescein-appearancetime data. Thus, acetazoleamide induced a fall in intraocular pressure without change in facility of outflow and associated with a delay in the appearance of fluorescein. Confirmatory evidence for this thesis has been obtained recently by measuring the change in rate of turnover of test substances in the eye and the alterations in the composition of the aqueous humor following acetazoleamide administration.‡ Of great theoretical significance have been the findings of inhibition of the carbonic anhydrase of the ciliary body
BECKER B, MIDDLETON WH. Long-Term Acetazoleamide (Diamox) Administration in Therapy of Glaucomas. AMA Arch Ophthalmol. 1955;54(2):187–192. doi:10.1001/archopht.1955.00930020191004
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