Difficulties in the clinical diagnosis of the eyes of two children with unilateral complete retrolental membranes, later studied pathologically, have stimulated this report. Both eyes were enucleated because of the possibility of a tumor, but histologic examination demonstrated the lesions to have been the result of massive subretinal hemorrhage with partial organization.
A number of conditions other than retinoblastoma must be considered in the differential diagnosis of eyes with clinical evidence of a retrolental membrane or of a progressively enlarging retinal or subretinal mass. The term "pseudoglioma" has frequently been used to describe this group of diseases, the specific diagnosis of which is often possible only after histologic study. Even then, in advanced stages the findings may be inconclusive. A number of excellent reviews on this subject have appeared in the recent literature.* Those diseases which are usually included under the name "pseudoglioma" follow.
FRAYER WC. Coats' Disease: A Clinical and Pathologic Study. AMA Arch Ophthalmol. 1955;54(2):240–244. doi:10.1001/archopht.1955.00930020246011
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