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September 1955

Experimental Tonography: The Effect of the Carbonic Anhydrase Inhibitor Acetazoleamide on Aqueous Flow

Author Affiliations

St. Louis
From the Department of Ophthalmology, Washington University School of Medicine, and the Oscar Johnson Institute.

AMA Arch Ophthalmol. 1955;54(3):321-329. doi:10.1001/archopht.1955.00930020327001

The use of tonography for the measurement of absolute rate of aqueous flow is subject to a number of possible errors.1 Many of these inaccuracies can be largely avoided when repeated tonography on the same eye is used for the evaluation of relative alterations in aqueous flow. Thus, in a series of 59 normal and glaucomatous eyes, repeated tonographic tracings before and three hours after oral acetazoleamide administration revealed an estimated average suppression of secretion of aqueous of 61%.*

Recently Kornblueth and Linnér † have presented evidence that tonography can be applied to rabbit eyes, using average values for ocular rigidity and corneal curvature. In the present investigation an attempt was made to quantitate the alteration in rabbit aqueous flow induced by carbonic anhydrase inhibition.

METHODS  Rabbits weighing 2-3 kg. were obtained from Haskins Rabbitry, St. Louis. In order to obtain a supply of "nonresponsive" rabbits, additional supplies

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