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September 1955

Isoniazid and Ocular Tuberculosis: An Evaluation of Experimental and Clinical Studies

Author Affiliations

Wilmington, Del.

AMA Arch Ophthalmol. 1955;54(3):330-344. doi:10.1001/archopht.1955.00930020336002

Isoniazid (isonicotinic acid hydrazide, known by the trade names of Nydrazid and I. N. H.) first attained prominence in the literature in 1952, at which time multiple studies were reported on its effectiveness, experimentally and clinically, in the therapy of pulmonary and other forms of tuberculosis.*

Isoniazid is a white, crystalline solid, freely soluble in water at any pH. It is poorly soluble in the common inert organic solvents, such as ethanol, ether, and benzene. In a dry state and in neutral and acid aqueous solutions, it is stable at room temperatures. Biological fluids, feces, and aqueous solutions containing isoniazid can be autoclaved for one hour at 15 lb. of pressure without destruction of the isoniazid in them provided the material is made acid before heating.16

From the reports16 on toxicity studies in several species of animals, it has been shown that both isoniazid and its isopropyl derivatives

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