[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
September 1955

Carbohydrate metabolism of Lens

Author Affiliations

From Howe Laboratory of Ophthalmology and Department of Biochemistry, Harvard Medical School, and Massachuetts Eye and Ear Infirmary.

AMA Arch Ophthalmol. 1955;54(3):360-368. doi:10.1001/archopht.1955.00930020366005

It has been generally assumed that the glucose metabolism in the lens is similar to that which predominates in other tissues. In most mammalian tissues glucose is catabolized first anaerobically to lactic acid by a process known as the glycolytic pathway and thence aerobically to carbon dioxide by a process known as the citric acid cycle. But the peculiar avascularity of the lens and its low oxygen consumption do not allow one to make any a priori assumptions as to the utilization of glucose by the lens. It is known that oxygen is essential for the maintenance of the viability of the lens,1 but heretofore no study has been made of pathways in the lens other than the classical types just referred to.

The present paper reports a study of aerobic pathways of carbohydrate metabolism and a quantitative evaluation of their relative importance. It will be pointed out that