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October 1955

Cataracts Induced by Alloxan Diabetes in Rats and Rabbits: Experimental Studies

Author Affiliations

Nashville, Tenn.; Iowa City
From the Departments of Ophthalmology and Anatomy, State University of Iowa College of Medicine.

AMA Arch Ophthalmol. 1955;54(4):564-572. doi:10.1001/archopht.1955.00930020570009

The present study was undertaken with the object of determining whether the progression of cataract formation, when the latter is induced by diabetes, might be altered by the following procedures: (a) feeding of diets containing an excess of nicotinic acid, (b) the injection of cysteine, or (c) maintenance of the animals in an atmosphere of 38%-40% oxygen. In addition, a comparison has been made of cataract formation in rats and rabbits as observed with the ophthalmoscope. In order to verify and supplement these observations, the lenses have been studied histologically.

In a previous publication1 it was noted that when diets containing excess nicotinic acid were fed to diabetic rats there was some delay in cataract formation. This could have resulted either from a lower food intake of the nicotinic-acid-fed group or from some effect of the nicotinic acid per se. In the present study the paired-feeding method was used

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