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November 1955

Adrenosem (Carbazochrome) in Primary Glaucoma and Diabetic Retinopathy

Author Affiliations

Louisville; Surat, India
From the University of Louisville School of Medicine, Section on Ophthalmology.

AMA Arch Ophthalmol. 1955;54(5):665-669. doi:10.1001/archopht.1955.00930020671006

Adrenochrome is one of the principal oxidation products of epinephrine and has no significant pressor action. It has been studied in Europe since 1937 and in America since 1951 for its action in control of bleeding from capillaries and venules. Its role seems independent of the chemistry of coagulation, the vitamin K-prothrombin mechanism, and the function of heparin or the usual anticoagulants. It is alleged to reduce capillary permeability and to increase capillary resistance,* a statement echoing data in regard to rutin several years ago. Both natural and synthetic adrenochrome are markedly unstable and insoluble. Evolution of the adrenochrome monosemicarbazone sodium salicylate complex has overcome these chemical difficulties. This product is synthetically prepared in America under the trade name Adrenosem and the generic name of carbazochrome.

PREVIOUS REPORT  In an uncontrolled, preliminary report of 69 private patients with bleeding problems, Sherber4 found gratifying clinical courses following carbazochrome administration in