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November 1955

Experimental Tonography in Rabbits: Effect of Unilateral Ligation of Common Carotid Artery on Aqueous Humor Dynamics As Studied by Means of Tonography and Fluorescein Appearance Time

Author Affiliations

Jerusalem; Uppsala, Sweden
From the Wilmer Ophthalmological Institute of The Johns Hopkins University and Hospital.; Hadassah - Rothschild - University (Dr. Kornbluth); University of Uppsala (Dr. Linnér).

AMA Arch Ophthalmol. 1955;54(5):717-724. doi:10.1001/archopht.1955.00930020723014

Clinical tonography, described by Grant10 in 1950, has proved of value for the study of the mechanism of aqueous flow under physiological and pathological conditions. It is of great help in the diagnosis of glaucoma and in the evaluation of the therapeutic effect of drugs and of surgery in glaucoma. Though the simplifying assumption involved in the interpretation and calculation from the tonographic tracings necessarily introduces some systematic errors, these do not detract appreciably from the value of tonography as a means of exploring problems of aqueous flow.

The purpose of this study was to investigate under experimental conditions one vascular factor which might influence aqueous flow and to see whether tonography in experimental rabbits could be used as an effective tool for the analysis of the effects.

Tonography in rabbits was reported only briefly by Grant.10 He stated that recordings were made on rabbit eyes in the