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December 1955

Intraocular Penetration of Locally Applied Steroids

Author Affiliations

Wills Eye Hospital, Department of Research.

AMA Arch Ophthalmol. 1955;54(6):916-921. doi:10.1001/archopht.1955.00930020922017

Hydrocortisone acetate (Compound F acetate) has been shown to be superior to cortisone acetate (Compound E acetate) as an antiphlogistic agent in the treatment of many external ocular lesions, such as vernal conjunctivitis and episcleritis. This superiority, however, is not apparent in the treatment of anterior segment intraocular inflammation, such as uveitis, by local instillation of drops.* The free-alcohol form of hydrocortisone is considered to be more effective than the acetate in the treatment of intraocular lesions by local administration.†

In a recent publication from this laboratory4 it was shown that hydrocortisone acetate entered the anterior chamber of rabbit eyes less rapidly and to a less extent than did cortisone acetate after local application. This observation may explain the difference in the relative efficacy of the two steroid acetates in the treatment of intraocular inflammation. If the extent of penetration of the drug is an important determinant of the