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December 1955

Potencialización farmacodinamica en oftalmologia.

AMA Arch Ophthalmol. 1955;54(6):959. doi:10.1001/archopht.1955.00930020965027

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Taking as a basis the theories of Laborit and Huguenard who in 1955 published the first results of a technique of anesthesia, which they called "General Anesthesia Without General Anesthetic Agents," the author applies these results to anesthesia in ophthalmic surgery. This technique is based on the following three points: conscious suppression of pain; akinesia or suppression of the motor impulses to the striate muscles, and elimination of defense reflexes of the neurovegetative system. This is achieved with the following combination of pharmacological agents: barbiturates (phenobarbital [Luminal], pentobarbital [Nembutal] and thiopental [Pentothal] ); ganglioplegics (diethazine [Diparcol], promethazine [Phenergan], hexamethonium, procaine, and chlorpromazine [Largactil]; analgesics (meperidine [Dolantin]); curare-like drugs (curare [Curarine] ); parasympathicolytic agents (atropine); sympathicolytic agents (ergotamine and hydergine [three hydrogenated ergot alkaloids]), and local instillation anesthetics (tetracaine 2% and cocaine 10% solution). This book includes statistics of the cases in which this method was used, illustrations of ocular nerve supply, and

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