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January 1956

The Radioactive Phosphorus (P32) Uptake Test in Ophthalmology: A Review of the Literature and Analysis of Results in Two Hundred Sixty-Two Cases of Ocular and Adnexal Pathology

Author Affiliations

Philadelphia; Harrisburg, Pa.
From the Research Department, Wills Eye Hospital.

AMA Arch Ophthalmol. 1956;55(1):52-83. doi:10.1001/archopht.1956.00930030054011

During the past two decades there has evolved a new phase of exploration in medical science dealing with the application of artificial radioactive isotopes in medical research. Recent studies by Thomas and associates,* Town,† Dunphy and associates,‡ Eisenberg and associates,§ and Kennedy and associates9 indicate the usefulness of radioactive phosphorus in the diagnosis of intraocular neoplasms. The present study was undertaken in order to gain more experience in the use of P32 in a variety of ocular pathologic conditions and to enlarge upon the original series of cases in this laboratory, to develop a method which would differentiate between inflammation and neoplasm, and to apply this technique, if possible, to the ocular adnexa.

Artificial radioactivity was discovered by Curie and Joliot10 in 1934, but it was not until 1936, when Lawrence ∥ and his associates developed the cyclotron, that the supply of artificially produced radioisotopes became sufficiently