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February 1956

Necroscleritis Nodosa: Clinicopathologic Report of a Case

Author Affiliations

Ann Arbor, Mich.
Department of Ophthalmology (Dr. Petrohelos) and Laboratory of Neuropathology and Neuro-Ophthalmology (Dr. Wolter), Neuropsychiatric Institute, University Hospital.

AMA Arch Ophthalmol. 1956;55(2):221-228. doi:10.1001/archopht.1956.00930030225008

Necroscleritis nodosa, a degenerative condition of the sclera of unknown etiology, has only recently been recognized as a clinical entity. Its pathologic characteristics are as yet not sufficiently known to enable the ophthalmologist to differentiate this disease from brawny scleritis or scleromalacia perforans.

HISTORICAL BACKGROUND  Van der Hoeve (1930) presented before the Dutch Ophthalmological Society two cases of a new degenerative entity of the sclera which he named scleromalacia perforans. The same author,1 in 1934, reported in more detail two of Rochat's cases2 and two of his own. Verhoeff and King3 and, more recently, Franceschetti and Bischler4 clarified this constitutional entity. They emphasized its differential diagnosis and separated it from simulating scleral diseases. Franceschetti suggested that the term perforating scleromalacia should be reserved for cases with little or no inflammatory reaction and associated with rheumatoid arthritis. The term nodular necrotizing scleritis, on the other hand, was

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