[Skip to Content]
[Skip to Content Landing]
February 1956

Allergic Granulomatous Angiitis Associated with Uveoscleritis and Papilledema

AMA Arch Ophthalmol. 1956;55(2):261-266. doi:10.1001/archopht.1956.00930030265013

Allergic granulomatous angiitis is one of the group of collagen diseases characterized by necrotizing lesions permeated with eosinophiles. The first clinical report of a similar disease was called periarteritis nodosa by von Rokitansky1 in 1852. Kussmaul and Maier2 described the pathological findings in 1866. Periarteritis nodosa, a systemic disease with ocular manifestations, was subdivided into three distinct pathological entities by Zeek.3 One of these subdivisions, allergic granulomatous angiitis of the eye, has received little mention in the literature. An opportunity to study the eye of a patient with this disease presented itself at the Eno Laboratory of the New York Eye and Ear Infirmary in March, 1954, following enucleation at Lenox Hill Hospital.

REPORT OF A CASE  A woman of European origin, 67 years old, was admitted to New York Hospital in May, 1949, complaining of anorexia, weight loss, and severe weakness. Indistinct margins of the optic