Recent clinical trials of prednisone therapy in active rheumatoid disease have revealed a potency several times as high as that of cortisone and its analogues.* Of added significance is the absence of a corresponding increase of side-effects, indicating that this drug may apparently be more suitable for long-term steroid therapy.
This report concerns an initial evaluation of prednisone in the treatment of ocular inflammation. For this purpose, the investigation was carried out in two parts: an examination of the response in experimental uveitis and a second, clinical study.
EXPERIMENTAL UVEITIS STUDIES
Evaluation of the anti-inflammatory action of prednisone was based on the results of three series of animal experiments: The initial two were carried out by collating the drug with cortisone, hydrocortisone, and corticotropin (ACTH), while the third served to examine prednisone potency alone. Significant features of the series were as follows:Experimental uveitis was induced by the intravitreal injection
O'ROURKE JF, ISER G, RYAN RW. An Initial Evaluation of Prednisone Therapy in Ocular Inflammation. AMA Arch Ophthalmol. 1956;55(3):323–332. doi:10.1001/archopht.1956.00930030327004
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