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March 1956

An Initial Evaluation of Prednisone Therapy in Ocular Inflammation

Author Affiliations

Bethesda, Md.
Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Department of Health, Education, and Welfare (Drs. O'Rourke and Iser).

AMA Arch Ophthalmol. 1956;55(3):323-332. doi:10.1001/archopht.1956.00930030327004

Recent clinical trials of prednisone therapy in active rheumatoid disease have revealed a potency several times as high as that of cortisone and its analogues.* Of added significance is the absence of a corresponding increase of side-effects, indicating that this drug may apparently be more suitable for long-term steroid therapy.

This report concerns an initial evaluation of prednisone in the treatment of ocular inflammation. For this purpose, the investigation was carried out in two parts: an examination of the response in experimental uveitis and a second, clinical study.

EXPERIMENTAL UVEITIS STUDIES  Evaluation of the anti-inflammatory action of prednisone was based on the results of three series of animal experiments: The initial two were carried out by collating the drug with cortisone, hydrocortisone, and corticotropin (ACTH), while the third served to examine prednisone potency alone. Significant features of the series were as follows:Experimental uveitis was induced by the intravitreal injection

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