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June 1956

Glucose Utilization of the Retina: IV. Influence of Toxic Substances and Enzyme Inhibitors

Author Affiliations

From the Department of Ophthalmology, Rothschild-Hadassah-University Hospital, and the Department of Pathological Physiology of the Hebrew University Medical School.

AMA Arch Ophthalmol. 1956;55(6):813-817. doi:10.1001/archopht.1956.00930030817007

Since carbohydrates are the main source of energy of the retina, it was thought that the glucose uptake of the retina might be an indicator of chemical damage to the retinal metabolism.

This report deals with the influence on the glucose uptake of the retina of some substances which are known to cause toxic amblyopia (methyl alcohol, quinine, arsenicals) and of compounds which damage the visual cells (iodoacetic acid, sodium iodate). Because of the close relationship of the carbohydrate metabolism to the resynthesis of acetylcholine, it was thought that cholinesterase inhibitors might influence the glucose uptake of the retina. Therefore the effects of physostigmine and isoflurophate (DFP; diisopropyl fluorophosphate) were investigated. Since a high concentration of carbonic anhydrase is present in the retina,1 the influence of the carbonic anhydrase inhibitor acetazoleamide (Diamox) was tested. The effects of ethionine, a competitive antagonist of methionine, and of the folic acid antagonist

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