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July 1956

Ocular Chrysiasis

Author Affiliations

Ann Arbor, Mich.
Department of Ophthalmology (Dr. Roberts) and Laboratory of Neuropathology and Neuro-Ophthalmology, Neuropsychiatric Institute (Dr. Wolter), University Hospital.

AMA Arch Ophthalmol. 1956;56(1):48-52. doi:10.1001/archopht.1956.00930040052007

Chrysiasis, a deposition of metallic gold in human tissues, may occur after repeated parenteral administration of gold salts. Reported cases of gold impregnation of the ocular tissues are sufficiently rare to warrant inclusion of the present case in the literature.

The ocular changes which may be observed after intensive gold salt therapy for arthritis, tuberculosis, and lupus erythematosus have been adequately summarized by Thomas.1 It is apparent that metallic gold may be deposited in the corneal stroma, in Descemet's and Bowman's membranes, and in the conjunctiva.* Some investigators have implied that the reduction of gold salts and the eventual deposition of gold particles in the tissues occurs mainly in those areas which have been exposed to light; however, perusal of the literature suggests that gold deposition may occur anywhere within the reticuloendothelial system and the connective tissue.†

Report of a Case  A 44-year-old white housewife was referred to the