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November 1956

A Further Study of Streptococcus Vaccines in Nongranulomatous Uveitis

Author Affiliations

From the Wilmer Ophthalmological Institute of the Johns Hopkins Hospital and University.

AMA Arch Ophthalmol. 1956;56(5):749-755. doi:10.1001/archopht.1956.00930040757015

In 1953 a report1 was made on the diagnostic and therapeutic use of Streptococcus vaccines in nongranulomatous uveitis. In this paper the cutaneous reactions to the vaccines shown by 101 patients with nongranulomatous uveitis were compared with those observed in 107 patients with the granulomatous form of the disease. The incidence of foci of infection and the evidences of systemic granulomatous disease in the two groups were also determined. In addition, the results of desensitization therapy in 36 patients were reported. The important conclusions drawn from this study were as follows:

  1. Patients with nongranulomatous uveitis show a high incidence of bacterial hypersensitivity (89%) as compared with patients with granulomatous uveitis (20%).

  2. With occasional exceptions, this hypersensitivity was to one or more strains of streptococci, Subgroups A of the β-streptococci and the alpha group being the most important.

  3. The intravenous administration of a specific Streptococcus vaccine in