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December 1956

Increase of Residual Protein of Bovine Vitreous During Growth of the Eye

Author Affiliations

San Francisco
Francis I. Proctor Foundation for Research in Ophthalmology, University of California Medical Center.

AMA Arch Ophthalmol. 1956;56(6):861-864. doi:10.1001/archopht.1956.00930040873008

It seems to be accepted1 that if the volume of the eye increases during pathological growth, such as in myopia, the increased space is not filled with normal gel-like vitreous but rather with a "liquid vitreous." Our interest has been to determine whether, during normal growth, the increased volume of the eye is occupied by a gel-like vitreous or by the secretion of a "liquid vitreous" into a preformed residual protein structure. It has been reported by Bembridge and Pirie2 that the rabbit probably commences to secrete hyaluronic acid into the vitreous only after birth. Balazs3 indicates that the vitreous hyaluronic acid and ascorbic acid contents parallel the increase in the vitreous during growth, while calcium and the soluble proteins of the vitreous decrease slightly from birth to adulthood. Information is not available pertaining to the rate of formation of the residual protein.

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